Krystexxa® (Pegloticase) IV Infusion Therapy

Advanced Treatment for Chronic Gout Not Controlled by Oral Medications

Clearwell Infusion Centers provides expert administration of Krystexxa (pegloticase) infusions for patients living with chronic gout that hasn’t responded to conventional therapy. Our Miami center offers private suites, flexible scheduling, and personalized care to help reduce uric acid levels and manage painful flares.

What Is Krystexxa?

Krystexxa® (pegloticase) is an FDA-approved biologic medication used to treat uncontrolled gout in adults. It is a recombinant enzyme that helps break down uric acid into a more easily eliminated substance, significantly lowering serum urate levels.

Krystexxa is administered as an intravenous (IV) infusion every 2 weeks, typically over a 6-month course. It’s often used when oral urate-lowering therapies such as allopurinol or febuxostat have failed or are not tolerated.

Learn more at the official Krystexxa website.

Who Is Krystexxa For?

Krystexxa is indicated for adult patients with:

• Chronic gout or tophaceous gout
• Serum uric acid levels that remain high despite treatment
• Frequent flares, joint damage, or visible urate crystal deposits
• Intolerance or inadequate response to oral urate-lowering medications

Patients must be carefully evaluated and monitored due to potential allergic and infusion-related reactions.

Krystexxa Side Effects

Krystexxa may cause side effects, including serious allergic reactions. To minimize this risk, premedication and monitoring protocols are followed with every infusion.

Common side effects include:

• Infusion reactions (rash, chest tightness, flushing)
• Nausea
• Headache
• Gout flares (especially during early treatment)
• Fatigue or shortness of breath

To help reduce the risk of gout flares during Krystexxa treatment, your doctor may recommend prophylactic medications such as colchicine or NSAIDs. For full safety information, visit the Krystexxa prescribing information.

Why Choose Clearwell for Your Krystexxa Infusion?

Clearwell Infusion Centers in Miami offers a safe, comfortable, and supportive setting for biologic infusions like Krystexxa. When you receive care at Clearwell, you benefit from:

• Private treatment suites with spa-like amenities
• Low patient-to-nurse ratio for attentive care
• Flexible appointment times, including weekends and evenings
• Comprehensive insurance coordination, including prior authorizations and benefits checks
• ACHC-accredited facility and safety standards
• Close coordination with your prescribing provider and care team

Our experienced infusion nurses monitor for side effects and ensure that patients complete treatment safely and comfortably.

Getting Started with Krystexxa Treatment

If your rheumatologist or provider has prescribed Krystexxa, we’ll help you begin treatment promptly. Clearwell handles insurance approvals, pre-treatment lab coordination, and ongoing communication with your care team.

Questions? Call us at 305‑306‑7147 or email contact@clearwellinfusion.com.

Referring Providers: Partner with Clearwell Infusion Centers

Clearwell Infusion Centers partners with rheumatologists, nephrologists, and primary care providers to administer Krystexxa in a monitored outpatient setting.

Why refer your patients to Clearwell?

• Quick turnaround for benefits verification and prior auths
• Simple referral process with same-week scheduling
• Clinical updates and documentation shared with your office
• Experienced staff following FDA-approved Krystexxa protocols
• ACHC-accredited infusion standards and safety monitoring

To refer a patient for Krystexxa infusion in Miami, contact our provider team at referrals@clearwellinfusion.com or call 305‑306‑7147.

Looking to start your Krystexxa treatment at Clearwell Infusion Centers?

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