Onpattro® (Patisiran) IV Infusion Therapy

RNAi Therapy for Hereditary Transthyretin-Mediated Amyloidosis (hATTR) with Polyneuropathy

Clearwell Infusion Centers offers expert administration of Onpattro (patisiran) for patients with hATTR amyloidosis. Our Miami-based infusion center provides private suites, personalized attention, and flexible scheduling to support long-term therapy in a comfortable, outpatient setting.

What Is Onpattro?

Onpattro® (patisiran) is an FDA-approved RNA interference (RNAi) therapy indicated for the treatment of adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR). It works by silencing the TTR gene, reducing the production of transthyretin protein that causes amyloid buildup in tissues.

Onpattro is administered as a once-every-3-weeks IV infusion, making it a convenient and targeted treatment option for this rare condition.

Learn more at the official Onpattro website.

Who Is Onpattro For?

Onpattro is prescribed for adults with hATTR amyloidosis with polyneuropathy, a progressive, inherited disease that affects the nerves, heart, and other organs. Patients typically experience symptoms such as:

• Numbness, tingling, or pain in the limbs
• Muscle weakness
• Gastrointestinal issues
• Orthostatic hypotension
• Cardiomyopathy (in some cases)

Onpattro may be used as a disease-modifying therapy to slow nerve damage progression and improve quality of life.

Onpattro Side Effects

Onpattro is generally well tolerated, but side effects may include:

• Infusion-related reactions (flushing, back pain, nausea)
• Upper respiratory tract infections
• Fatigue
• Muscle spasms
• Cough or headache

Patients receiving Onpattro will also receive premedication to reduce the risk of infusion reactions. Clearwell’s clinical team monitors patients closely throughout each infusion using ACHC-accredited safety protocols.

For complete safety details, see the Onpattro prescribing information.

Why Choose Clearwell for Your Onpattro Infusion?

At Clearwell Infusion Centers in Miami, we provide a high-quality, supportive experience for patients managing rare and chronic conditions. With Clearwell, you’ll receive:

• Private treatment suites with spa-like amenities
• Low patient-to-nurse ratio for attentive care
• Flexible appointment times, including weekends and evenings
• Comprehensive insurance coordination, including prior authorizations and benefits checks
• ACHC-accredited facility and safety standards
• Close coordination with your prescribing provider and care team

Infusions typically take around 80 minutes and are scheduled every 3 weeks.

Getting Started with Onpattro Treatment

If your physician has prescribed Onpattro, Clearwell will handle benefit verification, scheduling, and ongoing coordination with your care team to ensure a smooth experience from start to finish.

Questions? Call us at 305‑306‑7147 or email contact@clearwellinfusion.com.

Referring Providers: Partner with Clearwell Infusion Centers

Clearwell Infusion Centers partners with neurologists, geneticists, cardiologists, and rare disease specialists to provide safe, consistent Onpattro administration in a convenient outpatient setting.

Why refer your patients to Clearwell?

• Quick insurance approvals and same-week starts
• Experienced clinical team trained in rare disease protocols
• Timely documentation and communication with your practice
• Strict adherence to FDA and manufacturer infusion guidelines
• ACHC-accredited standards for safety and care delivery

To refer a patient for Onpattro in Miami, contact our provider team at referrals@clearwellinfusion.com or call 305‑306‑7147.

Looking to start your Onpattro treatment at Clearwell Infusion Centers?

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