Zinplava® (Bezlotoxumab) IV Infusion Therapy

Preventing Recurrence of Clostridioides difficile (C. diff) Infection

Clearwell Infusion Centers provides Zinplava IV infusion therapy for patients at high risk of recurrent C. difficile infection. At our Miami-based facility, patients receive high-quality care in a comfortable outpatient environment with private suites, flexible scheduling, and personalized support.

What Is Zinplava?

Zinplava® (bezlotoxumab) is an FDA-approved monoclonal antibody used to reduce the recurrence of Clostridioides difficile infection in adults receiving antibiotic treatment for C. diff and who are at high risk of recurrence. It works by neutralizing toxin B, a key driver of C. diff symptoms and recurrence. Zinplava is administered as a single-dose IV infusion alongside standard-of-care antibiotic treatment.

Learn more at the official Zinplava website.

Condition Treated with Zinplava

Zinplava is indicated for:

• Prevention of recurrent C. difficile infection in adults who are receiving antibiotic treatment and are at high risk of recurrence

Risk factors include age over 65, prior C. diff infections, immunocompromised conditions, and use of proton pump inhibitors or extended hospital stays.

Zinplava Side Effects

Zinplava is generally well tolerated. Possible side effects include:

• Nausea
• Fever
• Headache
• Shortness of breath
• Hypertension
• Heart failure exacerbation (especially in those with existing CHF)

Our clinical team at Clearwell monitors all patients during and after infusions using ACHC-accredited safety protocols to ensure a safe and effective experience.

For full safety details, view the Zinplava Prescribing Information.

Why Choose Clearwell for Your Zinplava Infusion?

Clearwell Infusion Centers is committed to providing convenient, comfortable, and clinically excellent care. When you receive Zinplava at our Miami center, you’ll benefit from:

• Private treatment suites with spa-like amenities
• Low patient-to-nurse ratio for attentive care
• Flexible appointment times, including weekends and evenings
• Comprehensive insurance coordination, including prior authorizations and benefits checks
• ACHC-accredited facility and safety standards
• Close coordination with your prescribing provider and care team

Zinplava is administered as a single 60-minute infusion, typically given during or shortly after antibiotic therapy.

Getting Started with Zinplava

If you’ve been prescribed Zinplava, we’ll handle all aspects of your care—from verifying insurance coverage to communicating with your care team and scheduling your infusion.

To begin treatment, call us at 305‑306‑7147 or email contact@clearwellinfusion.com.

Referring Providers: Partner with Clearwell Infusion Centers

We work closely with infectious disease specialists, primary care providers, and hospital discharge teams to deliver timely Zinplava therapy for C. diff recurrence prevention.

Why refer to Clearwell?

• Fast benefits verification and scheduling
• Seamless intake and coordination with your team
• ACHC-accredited safety protocols for immunocompromised patients
• Timely documentation and communication with your office
• Comfortable outpatient experience that enhances patient adherence

To refer a patient for Zinplava infusion therapy in Miami, contact referrals@clearwellinfusion.com or call 305‑306‑7147.

Looking to start your Zinplava treatment at Clearwell Infusion Centers?

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